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Sleep disorders In humans and non-human primates, melatonin treatment in acute form speeds up sleep onset, facilitates its maintenance, or both, and triggers brain waves characteristic of sleep, irrespective of the time of day (Cruz-Sanabria et al

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Even so, the existing data reveal a dose-response that appear to be reasonably consistent by disease state and tissue type and that doses of around 20-40 mg SFN daily can be provided in practical dose form quantities